Bollywood comes to America in "Jaan-E-Mann," a love story and family film shot in New York City. Suhaan (Salman Khan) is a wannabe rock star and a suave and polished wordsmith. He is every girl's dream. Agastya (Akshay Kumar) is the loveable underdog, the tongue-tied nerd who unlike Suhaan can't seem to get a sentence out. He's more the dreamer, than the dream. Suhaan and Agastya are polar opposites with only one thing in common... their love for Piya (Preity Zinta).
The three are college friends, but neither Suhaan nor Agastya is able to tell Piya how they feel. Ten years pass. Suhaan is now a famous singer, Agastya an astronaut, and Piya a modern woman creating a path all her own. The three are going about their lives... until one sunny afternoon, when fate brings them together.